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T lymphocytes expressing the CC chemokine receptor 2 (CCR2) are major producers of interferon-gamma (IFN-gamma) in response to the cognate chemokine monocyte chemoattractant protein-1 (MCP-1) in the lymph nodes.
The chemokine receptor CCR2 is expressed by CCR2+ T lymphocytes, which include T helper cells (Th) and cytotoxic T lymphocytes (CTL). Although the role of CCR2 in Th/CTL-mediated immune responses in peripheral tissues has been extensively studied, the role of CCR2 in Ag-specific T cell responses in the lymph nodes has not been defined. In this study we show that CCR2+ T lymphocytes produce IFN-gamma and represent a major source of IFN-gamma in the lymph nodes in response to the cognate chemokine, MCP-1. The number of IFN-gamma+ T lymphocytes and the production of IFN-gamma in response to MCP-1 in the draining lymph nodes was markedly reduced in CCR2-deficient (CCR2(-/-)) mice. The reduction in lymph node IFN-gamma production in CCR2(-/-) mice was associated with markedly reduced IFN-gamma production by splenocytes in response to antigen-specific restimulation in vitro. In addition, the antigen-specific proliferation of T lymphocytes in response to Ag-presenting cells in vitro was markedly reduced in CCR2(-/-) mice. These results demonstrate that CCR2+ T lymphocytes represent a major source of IFN-gamma in the lymph nodes. They further suggest that CCR2+ T lymphocytes play an important role in the lymph nodes in Ag-specific T cell-mediated immune responses.Imaging, spectroscopy, and photophysics of a dual-emitter system.
We propose a dual-emitter system (DEMS), consisting of two fluorescent emitters that are in close proximity, but which are not fused together. We show that exciton transport in this system depends on the distance between the emitters. We obtain photophysical parameters of the individual excitons from time-res
What’s New In AutoCAD?
Embed Validation PDFs and save time: Your drawings and review documents are ready for review. Preview and validate documents for CAD use. (video: 1:45 min.)
Manipulate your drawings using SuperPoints:
All of the interactive elements in AutoCAD 2023 make it easy to reposition, scale, rotate, and reposition points, create tangent or intersecting lines, and use native X, Y, and Z directions. Choose between either SuperPoint or coordinate-based methods. (video: 1:00 min.)
Draw smarter with new Type Manager:
Type Manager in AutoCAD 2023 helps you use elements to shape your drawings by defining type styles, specifying scales and aspect ratios, and generating labels. (video: 1:15 min.)
Markup multi-layered drawings in a single window:
Multi-layer drawing previews are now available on pages that display layered models. (video: 1:10 min.)
Access Your AutoCAD and AutoCAD LT Design History from within AutoCAD LT 2023:
Reveal all the changes made to your previous drawings and easily access the history of your work. (video: 1:35 min.)
Add Scalable Shading Language (SST) to your drawings:
You can create and apply SST profiles that are stored with your model and linked to the origin point of the drawing. (video: 1:55 min.)
Enable the use of Grid references in annotations:
Insert annotations that always reference the grid, regardless of the active drawing view. (video: 1:15 min.)
Save designs for reuse:
Save designs to your hard drive or network share for reuse. AutoCAD 2023 is the first release of AutoCAD to support this feature. (video: 1:10 min.)
Multi-profile support for marking views and toolbars:
You can now create multi-profile annotations, use multiple profiles in the same drawing, and adjust profiles and profiles preferences. (video: 1:55 min.)
Shape Feature Contours with the Feature Contour command:
Define new ways to shape parts, such as by using Feature Contours. They can create contours for your lines, splines, arcs, and polygons. (video: 1:10 min.)
See your sheets in a 3
System Requirements For AutoCAD:
Minimum:
OS: Windows 7, 8, 10
Processor: Intel Core i5-2500
Memory: 8 GB
Graphics: NVIDIA GeForce GTX 660
DirectX: Version 11
Storage: 100 GB free space
Additional Notes: The game currently requires Windows 7 or later.
NVIDIA Surround requires an NVIDIA Kepler graphics card and the NVIDIA Surround plug-in in order to fully utilize Surround. The plug-in is available on Mac, Linux, and Windows.
See the Surround Compatibility Chart for full
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